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Hence, a loss of HDAC activity removes the breaks for pro-inflammatory gene expression and also leads to a corticoid-resistant inflammatory phenotype

However, the 1950s were a different time, where the advertising and cultural pressure to smoke was intense

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With a gradual increase in the age of smoking population, the actual number of smokers aged 50 or above indeed increased from around 231 300 in 2000 to 294 200 in 2021, representing an increase of nearly 30%, which accounts for over half of the total smoking population